NMNAT1

Nicotinamide nucleotide adenylyltransferase 1

PDB rendering based on 1gzu.
Identifiers
Symbols NMNAT1; NMNAT; PNAT1
External IDs OMIM608700 MGI1913704 HomoloGene39074 GeneCards: NMNAT1 Gene
EC number 2.7.7.1
Orthologs
Species Human Mouse
Entrez 64802 66454
Ensembl ENSG00000173614 ENSMUSG00000028992
UniProt Q9HAN9 Q3V449
RefSeq (mRNA) NM_022787 NM_133435.1
RefSeq (protein) NP_073624 NP_597679.1
Location (UCSC) Chr 1:
10 – 10.05 Mb
Chr 4:
148.84 – 148.86 Mb
PubMed search [1] [2]

Nicotinamide mononucleotide adenylyltransferase 1 is an enzyme that in humans is encoded by the NMNAT1 gene.[1][2][3] It is a member of the Nicotinamide-nucleotide adenylyltransferases.

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003).[supplied by OMIM][3]

References

  1. ^ Schweiger M, Hennig K, Lerner F, Niere M, Hirsch-Kauffmann M, Specht T, Weise C, Oei SL, Ziegler M (Mar 2001). "Characterization of recombinant human nicotinamide mononucleotide adenylyl transferase (NMNAT), a nuclear enzyme essential for NAD synthesis". FEBS Lett 492 (1–2): 95–100. doi:10.1016/S0014-5793(01)02180-9. PMID 11248244. 
  2. ^ Emanuelli M, Carnevali F, Saccucci F, Pierella F, Amici A, Raffaelli N, Magni G (Feb 2001). "Molecular cloning, chromosomal localization, tissue mRNA levels, bacterial expression, and enzymatic properties of human NMN adenylyltransferase". J Biol Chem 276 (1): 406–12. doi:10.1074/jbc.M008700200. PMID 11027696. 
  3. ^ a b "Entrez Gene: NMNAT1 nicotinamide nucleotide adenylyltransferase 1". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64802. 

Further reading